Recent Progress in Ruthenium-Catalyzed Asymmetric Functionalization of C(sp²)-H Bonds

doi:10.6023/cjoc202511025

Abstract

C-H bond activation has emerged as a powerful and sustainable strategy for organic synthesis, as it avoids substrate pre-functionalization and offers simplicity, efficiency, and environmental friendliness. Compared to noble metals like palladium, rhodium, and iridium, ruthenium catalysts are more cost-effective, stable, and readily accessible, positioning them as highly promising for C-H activation. Ruthenium-catalyzed asymmetric C-H functionalization provides a versatile route to structurally diverse chiral molecules. This progress of asymmetric C(sp²)-H bond functionalization in recent years is dicussed, classified by asymmetric induced reaction strategies. The reaction scope, functional group tolerance, reaction mechanisms, and limitations of these methods were covered, and the future outlook and existing challenges are also provided.

Key words: Ruthenium catalysis, Asymmetric catalysis, C-H bond activation, C-H bond functionalization

Cite this article

Liao Yun, Tang Li-Juan, Zong Yingtong, Yu Daohong. Recent Progress in Ruthenium-Catalyzed Asymmetric Functionalization of C(sp²)-H Bonds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202511025.

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钌催化C(sp²)-H键的不对称官能化研究进展