Advances in Visible-Light Induced Trifluoromethylation with Trifluoroacetic Acid and Its Anhydride as Inexpensive and Effective Trifluoromethylation Reagents

doi:10.6023/cjoc202603009

Abstract

The triﬂuoromethyl group plays a crucial role in pharmaceuticals, agrochemicals, and materials science, driving extensive efforts in the discoveries of new trifluoromethylating reagents and the development of methods for introducing this group into molecular frameworks. Over the past decade, the field of visible-light photocatalysis has flourished. Visible-light photocatalytic trifluoromethylation, as a green and efficient synthetic strategy, has emerged as an important method for constructing trifluoromethyl-containing molecules with broad application prospects. This article systematically reviews the research progress of exploring on triﬂuoroacetic acid and its anhydride as inexpensive and effective triﬂuoromethyl reagents for visible-light catalyzed triﬂuoromethylation reactions. It focuses on key scientific issues such as activating methods, reaction mechanisms, and transformations. The insights gained are expected to facilitate the rational design of effective photocatalytic strategies for future utilization of triﬂuoroacetic acid or its anhydride.

Key words: trifluoromethylation, triﬂuoroacetic acid and its anhydride, visible-light photocatalysis, LMCT

Cite this article

Bin Huang, Zhantu Xu, Jing Chen, Weiping Su, Chen Zhu. Advances in Visible-Light Induced Trifluoromethylation with Trifluoroacetic Acid and Its Anhydride as Inexpensive and Effective Trifluoromethylation Reagents[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603009.

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