We report an environmentally friendly and highly efficient electrochemical protocol for the synthesis of vinyl sulfones. This method enables the direct coupling of readily available sulfonyl hydrazides with alkenes under mild, metal-free, exogenous oxidant-free and iodide-additive-free conditions, delivering the corresponding vinyl sulfones in excellent yields. The protocol features broad substrate scope, good functional group tolerance and is amenable to gram-scale synthesis. Moreover, the prepared vinyl sulfone derivatives exhibit excellent anti-proliferative activity against osteosarcoma cell lines. This work provides a practical and sustainable alternative for the green synthesis and medicinal research of valuable vinyl sulfone compounds.

Key words: Vinyl sulfones, Electrochemical synthesis, Metal-free catalysis, Green synthesis