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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 4: 1210 - 1215

DOI: https://doi.org/10.6023/cjoc202110022

ARTICLES

Construction of Diaminobenzoquinone Imines through Radical Coupling of Aminophenols with Amine under UV-Light

  • Limei Xu ,
  • Linyan Lu ,
  • Jinzhong Cai ,
  • Yadong Feng ,
  • Xiuling Cui
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  • a College of Environment and Public Health, Xiamen Huaxia University, Xiamen, Fujian 361024
    b Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian 361021
* E-mail: ;

Received date: 2021-10-15

  Revised date: 2021-11-17

  Online published: 2021-12-02

Supported by

Fujian Education and Scientific Research Project for Young and Middle-Aged Teachers(JAT190990)

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Abstract

A metal-free radical coupling reaction of aminophenols with amines under UV-light has been successfully developed to synthesize diaminobenzoquinone imines in high yields, in which the commercially available and cheap t-butyl hydroperoxide (TBHP) was used as an oxidant. This protocol provides an easy and green approach for the construction of benzoquinone imines with potential pharmaceutical interest avoiding metal catalyst or photocatalyst.

Key words： UV-light; radical coupling; metal-free; diaminobenzoquinone imines

Cite this article

Limei Xu , Linyan Lu , Jinzhong Cai , Yadong Feng , Xiuling Cui . Construction of Diaminobenzoquinone Imines through Radical Coupling of Aminophenols with Amine under UV-Light[J]. Chinese Journal of Organic Chemistry, 2022 , 42(4) : 1210 -1215 . DOI: 10.6023/cjoc202110022

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