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Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp3)—H Bonds Enabled by AsPh3/Iridium Catalysis
Received date: 2021-11-23
Revised date: 2021-12-08
Online published: 2021-12-15
Supported by
National Natural Science Foundation of China(91956116); National Natural Science Foundation of China(21776260)
The AsPh3/iridium catalyzed diborylation of unactivated primary C(sp3)—H bonds using pyrazoles as directing groups was disclosed. This method could tolerate a variety of functional groups, affording a vast array of 1,1-diboron alkanes in moderate to good yields. The synthetic utility of the current method on a gram-scale reaction for further functionalization was also demonstrated.
Key words: C—H borylation; organoboron; synthetic methods; iridium
Wenqi Liu , Zhenlu Shen , Senmiao Xu . Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp3)—H Bonds Enabled by AsPh3/Iridium Catalysis[J]. Chinese Journal of Organic Chemistry, 2022 , 42(4) : 1101 -1110 . DOI: 10.6023/cjoc202111032
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