Chinese Journal of Organic Chemistry >
Visible Light-Induced Hydroxyalkylation of Heteroarenes with Aliphatic Alcohols
Received date: 2021-12-25
Revised date: 2022-01-18
Online published: 2022-01-27
Supported by
Anhui Laboratory of Molecule-Based Materials(fzj21005)
An efficient visible light-induced direct cross-dehydrogenative coupling of heteroarenes with aliphatic alcohols in aqueous solution at ambient temperature was developed. The reaction is initiated by persulfate salts and does not require the use of stoichiometric acid for activation of the heterocycle. α-Hydroxyalkyl radicals transiently generated from alcohols via hydrogen atom transfer (HAT) undergo Minisci-type reactions with a range of heteroarenes. This protocol was highlighted by photocatalyst-free, green solvent, mild conditions, readily available starting materials, and wide functional group tolerance.
Dongping Xu , Fei Huang , Lin Tang , Xinming Zhang , Wu Zhang . Visible Light-Induced Hydroxyalkylation of Heteroarenes with Aliphatic Alcohols[J]. Chinese Journal of Organic Chemistry, 2022 , 42(5) : 1493 -1500 . DOI: 10.6023/cjoc202112032
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