Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1493-1500.DOI: 10.6023/cjoc202112032 Previous Articles     Next Articles



徐东平, 黄飞, 汤琳, 张新明, 张武*()   

  1. 安徽师范大学化学与材料科学学院 安徽芜湖 241000
  • 收稿日期:2021-12-25 修回日期:2022-01-18 发布日期:2022-01-27
  • 通讯作者: 张武
  • 基金资助:

Visible Light-Induced Hydroxyalkylation of Heteroarenes with Aliphatic Alcohols

Dongping Xu, Fei Huang, Lin Tang, Xinming Zhang, Wu Zhang()   

  1. College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000
  • Received:2021-12-25 Revised:2022-01-18 Published:2022-01-27
  • Contact: Wu Zhang
  • Supported by:
    Anhui Laboratory of Molecule-Based Materials(fzj21005)

An efficient visible light-induced direct cross-dehydrogenative coupling of heteroarenes with aliphatic alcohols in aqueous solution at ambient temperature was developed. The reaction is initiated by persulfate salts and does not require the use of stoichiometric acid for activation of the heterocycle. α-Hydroxyalkyl radicals transiently generated from alcohols via hydrogen atom transfer (HAT) undergo Minisci-type reactions with a range of heteroarenes. This protocol was highlighted by photocatalyst-free, green solvent, mild conditions, readily available starting materials, and wide functional group tolerance.

Key words: alcohol, cross-dehydrogenative coupling, heteroarene, hydroxyalkylation, visible light-induction