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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 9: 2682 - 2702

DOI: https://doi.org/10.6023/cjoc202204056

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Recent Progress in Transition Metal-Catalyzed C—H Bond Activation of N-Aryl Phthalazinones

  • Haichun Gu ,
  • Xinxin Jin ,
  • Jiaqi Li ,
  • He Li ,
  • Jinglin Liu
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  • a College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000
    b Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, Tongliao, Inner Mongolia 028000
* Corresponding authors. E-mail: ;

Received date: 2022-04-22

  Revised date: 2022-06-01

  Online published: 2022-06-17

Supported by

Inner Mongolia Natural Science Foundation(2020BS02014); Inner Mongolia Minzu University Doctoral Research Startup Fund Project(BS560)

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Abstract

N-Aryl phthalazinones are important nitrogen heterocycles widely existing in the natural products and drug molecules. Meanwhile, N-aryl phthalazinones are also very significant substrates for organic synthesis. In recent years, with the development of C—H bond activation catalyzed by transition metal, the synthesis of nitrogen heterocycles via the C—H bond cleavage of phthalazines derivatives has attracted attention of chemists. In this paper, the recent progress of the transition metal-catalyzed C—H bond activation reaction of phthalazines is reviewed by classifying different coupling components, and the reaction mechanism is discussed.

Key words： N-aryl phthalazinones; transition metal; C—H bond activation; coupling partners

Cite this article

Haichun Gu , Xinxin Jin , Jiaqi Li , He Li , Jinglin Liu . Recent Progress in Transition Metal-Catalyzed C—H Bond Activation of N-Aryl Phthalazinones[J]. Chinese Journal of Organic Chemistry, 2022 , 42(9) : 2682 -2702 . DOI: 10.6023/cjoc202204056

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