Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (9): 2682-2702.DOI: 10.6023/cjoc202204056 Previous Articles     Next Articles



顾海春a,b, 靳新新a,b, 李嘉琪a,b, 李贺a,b,*(), 刘景林a,b,*()   

  1. a 内蒙古民族大学化学与材料学院 内蒙古通辽 028000
    b 内蒙古自治区天然产物化学及功能分子合成重点实验室 内蒙古通辽 028000
  • 收稿日期:2022-04-22 修回日期:2022-06-01 发布日期:2022-06-16
  • 通讯作者: 李贺, 刘景林
  • 基金资助:
    内蒙古自然科学基金(2020BS02014); 内蒙古民族大学博士科研启动基金(BS560)

Recent Progress in Transition Metal-Catalyzed C—H Bond Activation of N-Aryl Phthalazinones

Haichun Gua,b, Xinxin Jina,b, Jiaqi Lia,b, He Lia,b(), Jinglin Liua,b()   

  1. a College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000
    b Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, Tongliao, Inner Mongolia 028000
  • Received:2022-04-22 Revised:2022-06-01 Published:2022-06-16
  • Contact: He Li, Jinglin Liu
  • Supported by:
    Inner Mongolia Natural Science Foundation(2020BS02014); Inner Mongolia Minzu University Doctoral Research Startup Fund Project(BS560)

N-Aryl phthalazinones are important nitrogen heterocycles widely existing in the natural products and drug molecules. Meanwhile, N-aryl phthalazinones are also very significant substrates for organic synthesis. In recent years, with the development of C—H bond activation catalyzed by transition metal, the synthesis of nitrogen heterocycles via the C—H bond cleavage of phthalazines derivatives has attracted attention of chemists. In this paper, the recent progress of the transition metal-catalyzed C—H bond activation reaction of phthalazines is reviewed by classifying different coupling components, and the reaction mechanism is discussed.

Key words: N-aryl phthalazinones, transition metal, C—H bond activation, coupling partners