SIOC 中文
CJOG
Adv search

Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 9: 2961 - 2966

DOI: https://doi.org/10.6023/cjoc202202016

NOTES

Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

  • Dan Huang ,
  • Xuhua Nong ,
  • Jianni Yang ,
  • Chen Li ,
  • Changri Han ,
  • Guangying Chen ,
  • Xiaoping Song ,
  • Zhenfan Sun ,
  • Yang Hui ,
  • Wenhao Chen
Expand
  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    c Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571126
† These authors contributed equally to this work
* Corresponding authors. E-mail: ;
;

Received date: 2022-02-13

  Revised date: 2022-03-28

  Online published: 2022-06-23

Supported by

National Natural Science Foundation of China(22167013); Key Project of Research and Development of Hainan Province(ZDYF2021SHFZ221); Hainan Provincial Natural Science Foundation of China(221RC541); Education Department of Hainan Province(Hnky2021ZD-10); Program for Hainan Provincial Graduate Innovation Research Project(Hys2021-72); Innovation Training Program for College Students(202111658002); Innovation Training Program for College Students(202111658003)

Fold

Abstract

Two new compounds, terrustone (1) and asperteretone G (2) together with ten known compounds were isolated from Scutellaria formosana endophytic fungus Aspergillus terreus HQ100X-1, terrustone (1) is a trihydroxycyclopentanone with four consecutive chiral centers. Their structures were determined by 1D/2D NMR data along with electrostatic circular dichroism (ECD) calculation for configurational assignment. Compound rbrolide R (4) showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 2.5 μg/mL.

Key words： scutellaria formosana; Aspergillus terreus; antibacterial activity

Cite this article

Dan Huang , Xuhua Nong , Jianni Yang , Chen Li , Changri Han , Guangying Chen , Xiaoping Song , Zhenfan Sun , Yang Hui , Wenhao Chen . Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana[J]. Chinese Journal of Organic Chemistry, 2022 , 42(9) : 2961 -2966 . DOI: 10.6023/cjoc202202016

References

[1]
Shang, X. F.; He, X. R.; He, X. Y.; Li, M. X.; Zhang, R. X.; Fan, P. C.; Zhang, Q. L.; Jia, Z. P. J. Ethnopharmacology 2010, 128, 279.
[2]
Bruno, M.; Piozzi, F.; Rosselli, S. Nat. Prod. Rep. 2002, 19, 357.
[3]
Dai, S. J.; Chen, M.; Liu, K.; Jiang, Y. T.; Shen, L. Chem. Pharm. Bull. 2006, 54, 869.
[4]
Dai, S. J.; Tao, J. Y.; Liu, K.; Jiang, Y. T.; Shen, L. Phytochemistry 2006, 67, 1326.
[5]
Dai, S. J.; Ling, D. D.; Ren, Y.; Liu, K.; Shen, L. Chem. Pharm. Bull. 2008, 56, 207.
[6]
Dai, S. J.; Peng, W. B.; Shen, L.; Zhang, D. W.; Ren, Y. J. Asian Nat. Prod. Res. 2009, 11, 451.
[7]
Dai, S. J.; Qu, G. W.; Yu, Q. Y.; Zhang, D. W.; Li, G. S. Fitoterapia 2010, 81, 737.
[8]
Wu, T. Z.; Wang, Q.; Jiang, C.; Susan, M. N.; Cui, H.; Wang, Y.; Yan, Y.; Xu, J. J. Nat. Prod. 2015, 78, 500.
[9]
Chen, X.; Chen, W. H.; Chen, G. Y.; Han, C. R.; He, J. J.; Zhou, X. M.; Yu, Z. X.; Dai, C. Y.; Song, X. P. Phytochemistry 2018, 145, 1.
[10]
Chen, X.; Chen, G. Y.; Chen, W. H.; Han, C. R.; Song, X. P.; Pan, Y. J. Chin. Med. Mater. 2016, 39, 2240. (in Chinese)
[10]
(陈欣, 陈光英, 陈文豪, 韩长日, 宋小平, 潘怡, 中药材, 2016, 39, 2240.)
[11]
Chen, X.; Chen, G. Y.; Chen, W. H.; Han, C. R.; Song, X. P.; Wu, Y. Chin. J. Trop. Agric. 2016, 36, 93. (in Chinese)
[11]
(陈欣, 陈光英, 陈文豪, 韩长日, 宋小平, 吴燕, 热带农业科学, 2016, 36, 93.)
[12]
Zhang, N. M.S. Thesis, Jinan University, Guangdong, 2019. (in Chinese)
[12]
(张娜, 硕士论文, 暨南大学, 广东, 2019.)
[13]
Liu, M. T.; Qi, C. X.; Sun, W. G.; Shen, L.; Wang, J. P.; Liu, J. J.; Lai, Y. J. Xue, Y. B.; Hu, Z. X.; Zhang, Y. H. Front. Chem. 2018, 6, 422.
[14]
Zhou, K.; Zhu, L.; Wang, X. L.; Zhang, T. D.; Wang, Y. D.; Dong, W.; Ji, B. K.; Yang, H. Y.; Du, G.; Hu, Q. F.; Zhou, M. Chem. Nat. Compd. 2016, 52, 591.
[15]
Pal, A.; Banik, B. K. Heterocycl. Lett. 2020, 10, 537.
[16]
Qi, C. X.; Gao, W. X.; Wang, J. P.; Liu, M. T.; Zhang, J. W.; Chen, C. M.; Hu, Z. X.; Xue, Y. B.; Li, D. Y.; Zhang, Q.; Lai, Y. J.; Zhou, Q.; Zhu, H. C.; Zhang, Y. H. Fitoterapia 2018, 130, 134.
[17]
Bao, J.; Li, X. X.; Zhu, K. L.; He, F.; Wang, Y. Y.; Yu, J. H.; Zhang, X. Y.; Zhang, H. Fitoterapia 2021, 150, 104856.
[18]
Cazar, M. E.; Schmeda-Hirschmann, G.; Astudillo, L. J. Microbiol. Biotechnol. 2005, 21, 1067.
[19]
Wang, Y.; Zheng, J. K.; Liu, P. P.; Wang, W.; Zhu, W. M. Mar. Drugs 2011, 9, 1368.
[20]
He, F.; Bao, J.; Zhang, X. Y.; Tu, Z. C.; Shi, Y. M.; Qi, S. H. J. Nat. Prod. 2013, 76, 1182.
[21]
Guo, F.; Li, Z. L.; Xu, X. W.; Wang, K. B.; Shao, M. L.; Zhao, F.; Wang, H. F.; Hua, H. M.; Pei, Y. H.; Bai, J. Fitoterapia 2016, 113, 44.
[22]
Parvatkar, R. R.; D'Souza, C.; Tripathi, A.; Naik, C. G. Phytochemistry 2009, 70, 128.
[23]
Song, X. M.; Zhou, X. M.; Li, X. B.; Zheng, C. J.; Huang, G. L.; Yu, Z. X.; Song, X. P.; Chen, G. Y. Chin. J. Org. Chem. 2015, 35, 2102. (in Chinese)
[23]
(宋鑫明, 周学明, 李小宝, 郑彩娟, 黄国雷, 余章昕, 宋小平, 陈光英, 有机化学, 2015, 35, 2102.)
Options
Outlines

/

〈 〉