Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (9): 2961-2966.DOI: 10.6023/cjoc202202016 Previous Articles     Next Articles


蓝花黄芩内生真菌Aspergillus terreus HQ100X-1次级代谢产物研究

黄丹a,b, 农旭华a,b, 杨建妮a,b, 李琛a,b, 韩长日c,*(), 陈光英a,b, 宋小平a,b, 孙振范c, 惠阳a,b,*(), 陈文豪a,b,*()   

  1. a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158
    b 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158
    c 海南科技职业大学 药食同源植物资源海南省重点实验室 海口 571126
  • 收稿日期:2022-02-13 修回日期:2022-03-28 发布日期:2022-06-22
  • 通讯作者: 韩长日, 惠阳, 陈文豪
  • 作者简介:
  • 基金资助:
    国家自然科学基金(22167013); 海南省重点研发项目(ZDYF2021SHFZ221); 海南省自然科学基金(221RC541); 海南省教育厅项目(Hnky2021ZD-10); 海南省研究生创新科研课题(Hys2021-72); 大学生创新创业训练计划(202111658002); 大学生创新创业训练计划(202111658003)

Study on the Secondary Metabolites of the Endophytic Fungus Aspergillus terreus HQ100X-1 in Scutellaria formosana

Dan Huanga,b, Xuhua Nonga,b, Jianni Yanga,b, Chen Lia,b, Changri Hanc(), Guangying Chena,b, Xiaoping Songa,b, Zhenfan Sunc, Yang Huia,b(), Wenhao Chena,b()   

  1. a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    c Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571126
  • Received:2022-02-13 Revised:2022-03-28 Published:2022-06-22
  • Contact: Changri Han, Yang Hui, Wenhao Chen
  • About author:
    These authors contributed equally to this work
  • Supported by:
    National Natural Science Foundation of China(22167013); Key Project of Research and Development of Hainan Province(ZDYF2021SHFZ221); Hainan Provincial Natural Science Foundation of China(221RC541); Education Department of Hainan Province(Hnky2021ZD-10); Program for Hainan Provincial Graduate Innovation Research Project(Hys2021-72); Innovation Training Program for College Students(202111658002); Innovation Training Program for College Students(202111658003)

Two new compounds, terrustone (1) and asperteretone G (2) together with ten known compounds were isolated from Scutellaria formosana endophytic fungus Aspergillus terreus HQ100X-1, terrustone (1) is a trihydroxycyclopentanone with four consecutive chiral centers. Their structures were determined by 1D/2D NMR data along with electrostatic circular dichroism (ECD) calculation for configurational assignment. Compound rbrolide R (4) showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) value of 2.5 μg/mL.

Key words: scutellaria formosana, Aspergillus terreus, antibacterial activity