Chinese Journal of Organic Chemistry >
Recent Advances in the Decarboxylative Acylation/Cyclization of α-Keto Acids
Received date: 2022-05-17
Revised date: 2022-06-23
Online published: 2022-07-05
Supported by
National Natural Science Foundation of China(21672028)
Decarboxylation of α-keto acids is a simple and efficient method to obtain corresponding acyl radicals. Cascade radical cyclization has been proved as efficient approach towards cyclic structures, especially heterocyclic ones. A variety of acylated cyclic compounds such as indolones, quinolinones, phenanthridines, coumarins, chromones, benzothiophenes, and pyrrole[1,2-a]indoles could be constructed using α-keto acids via the decarboxylative acylation/cyclization with acyl radicals as intermediates. This review focuses on the recent advances in the acylation/cyclization reaction triggered by acyl radicals that formed from the decarboxylation of α-keto acids.
Key words： α-keto acids; cyclization reaction; radical reaction; acylation
Yechun Wu , Jintao Yu . Recent Advances in the Decarboxylative Acylation/Cyclization of α-Keto Acids[J]. Chinese Journal of Organic Chemistry, 2022 , 42(11) : 3606 -3619 . DOI: 10.6023/cjoc202205025
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