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化学学报
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化学学报 ›› 1990, Vol. 48 ›› Issue (1): 78-82. 上一篇    下一篇

研究论文

樟脑酮亚胺衍生物的合成及立体结构研究

郭鹏;蒋耀忠;周忠远;郁开北   

  1. 中国科学院成都有机化学研究所;中国科学院成都分析测试中心
  • 发布日期:1990-01-15

The synthesis and structure study of camphor-imine derivative

GUO PENG;JIANG YAOZHONG;ZHOU ZHONGYUAN;YU KAIBEI   

  • Published:1990-01-15

PDF

395

被引次数

2

从d-樟脑出发, 经六步反应合成了一种新的樟脑酮亚胺衍生物──7,7-二甲基-双环[2,2,1]=2-(苄)亚胺-10-(N-邻羟基苯基酰胺(2)。化合物的晶体的晶胞参数a=8.6904(9), b=10.9400(16), c=20.8583(33)埃; Z=4; V=1983.06(0.45)埃^3; 属P212121空间群, 用反常散射法测定分子的绝对构型为1S, 4R, 并讨论了该化合物作为不对称反应合成子的立体选择的影响因素。

关键词: 晶体结构测定, Ｘ射线衍射分析, 萜类化合物, 晶胞, 立体选择性, 樟脑, 亚胺, 绝对构型, 酮 P, 酮酰胺

From (+)-camphor, a new camphor-imine derivative I is synthesized. The structure of I is determine by single crystal x-ray diffraction. The absolute configuration of the mol. is established by the anomalous dispersion method using 37 pairs of reflections. According to the structure, the stereoselectivity of I used as a chiral synthon is discussed.

Key words: CRYSTAL STRUCTURE DETERMINATION, X-RAY DIFFRACTION ANALYSIS, TERPENE, UNIT CELL, STEREOSELECTIVITY, CAMPHOR, IMINE, ABSOLUTE CONFIGURATION, KETONE P, KETOAMIDES

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