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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (23): 2620-2624. 上一篇    下一篇

研究论文

一类Fmoc保护二肽醇类凝胶因子的合成与凝胶化研究

谢志国 张爱英 叶 霖 冯增国*

  

  1. (北京理工大学材料科学与工程学院， 北京 110000008811)

  • 投稿日期:2008-05-21 修回日期:2008-07-07 发布日期:2008-12-14
  • 通讯作者: 冯增国

Synthesis and Gelation of a Series of Low-molecular-weight Gelators based on Fmoc-dipeptide in Alcoholic Solvents

XIE, Zhi-Guo ZHANG, Ai-Ying YE, Lin FENG, Zeng-Guo*   

  1. (Department of Material Science and Engineering,, Beijing Institute of Technology,, Beijing 11000008811)
  • Received:2008-05-21 Revised:2008-07-07 Published:2008-12-14
  • Contact: FENG, Zeng-Guo

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1507

被引次数

4 | 3

合成了一类Fmoc保护二肽凝胶因子(Fmoc-Lys(Fmoc)-Tyr-OR, R=＝Me, Et, Hex)，, 并通过加热溶解-冷却静置方法测试了其凝胶性能。. 它们可在多种脂肪醇类溶剂中形成有机凝胶，, 并且具有热可逆性。. 通过透射电镜发现，, R为Me的凝胶因子在正己醇中可自组装成纳米级纤维状结构，, 相互交织使溶剂得以固定形成半透明凝胶，, 而在正丙醇中则倾向自组装成多刺球状，, 形成不透明白色凝胶。. IR及荧光光谱分析结果表明氢键与π-π stacking作用参与了其凝胶化自组装，, 同时氢键在凝胶态的强度较其固态时降低。. 该结果也从XRD数据中得以进一步证实。

关键词: 凝胶因子, Fmoc保护二肽, 自组装

A series of Fmoc-Lys(Fmoc)-Tyr-OR (R=＝Me, Et, Hex) gelators were synthesized and characterized, which were found to gelate a number of aliphatic alcohols to give translucent or opaque thermo-reversible organogels. Nanofiber and spherulitic networks were evidenced in the self-assemblies in n-hexanol and n-propanol by TEM, respectively. IR and fluorescence studies revealed that the hydrogen bonding and π-π stacking acted as a significant driving force for the self-assembly. As a result, the intensity of hydrogen bonding in xerogel was lower than that in the solid, which was further confirmed by XRD analyses.

Key words: gelator, Fmoc-dipeptide, self-assembly