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化学学报
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化学学报 ›› 2011, Vol. 69 ›› Issue (02): 137-144. 上一篇    下一篇

研究论文

醇水介质中共沉淀法制备甲氨蝶呤/层状双氢氧化物纳米材料的研究

王继芹1，李鑫1，李淑萍*,1，仲慧2   

  1. (1江苏省生物功能材料重点实验室 南京师范大学化学与环境科学学院 南京 210097)
    (2淮阴师范学院化学与化工学院 淮阴 223300)
  • 投稿日期:2010-07-05 修回日期:2010-09-10 发布日期:2010-09-19
  • 通讯作者: 李淑萍 E-mail:lishuping2@yahoo.com.cn

Studies on Preparation of Methotrexatum/Layered Double Hydroxides Compounds by Coprecipitation Method in Ethanol-Water Medium

Wang Jiqin1 Li Xin1 Li Shuping*,1 Zhong Hui2   

  1. (1 Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097)
    (2 School of Chemistry and Chemical Engineering, Huaiyin Normal Univerisy, Huaiyin 223300)
  • Received:2010-07-05 Revised:2010-09-10 Published:2010-09-19

PDF

1188

被引次数

24

采用乙醇-水混合溶液为溶剂, 以NaOH为沉淀剂制备了甲氨蝶呤(MTX)-镁铝层状双氢氧化物(Mg-Al-LDH)纳米复合材料, 利用X-射线衍射(XRD)、透射电镜(TEM)和傅里叶变换红外(FT-IR)光谱等表征手段, 对其结构及形貌进行了系统研究. 研究表明, 与传统的水溶液共沉淀法相比, 醇水共沉淀法制备的MTX/LDH纳米复合物为球形片状, 粒径较小, 且分散性好. 研究了醇水体积比对MTX/LDH纳米复合物性质的影响, 结果表明, MTX分子以单层倾斜方式插入氢氧化物层间, 随着合成条件的变化倾斜角度发生改变. 当醇水体积比为1∶3时, 制得的粒子最小, 且大小均匀, 无团聚现象. 在磷酸缓冲液中考察了不同粒径MTX/LDH纳米复合物的缓释性能, 结果表明, 粒径小的MTX/LDH纳米粒子缓释效果优于粒径大的.

关键词: 层状双氢氧化物, 醇水共沉淀法, 甲氨蝶呤, 纳米复合材料, 体外释放

The methotrexatum (MTX) was intercalated into the layered double hydroxides (LDHs) to form the MTX/LDH compounds, by the coprecipitation method in the alcohol-water mixed solvent (alcohol-water co-precipitation for short) and NaOH as precipitator. The influence of alcohol-water solvent on the structure of MTX/LDH compounds was systematically investigated by X-ray diffraction (XRD), transmission electron micrograph (TEM), fourier transform infrared spectroscopy (FTIR) and differential thermal analysis (DTA) techniques. The studies indicated that compared with the conventional coprecipitation method in water solvent, the morphology of the particles prepared by the alcohol-water coprecipitation was spherical shape with smaller size and had a good dispersion. MTX anions were intercalated into the LDH sheets as a delined monolayer and the declined angles changed with the variation of the volume ratio of ethanol to water. Our results showed that when the volume ratio of alcohol to water was 1∶3, the particles are the smallest and uniform without agglomeration. At last, the drug release rates with different particles size were studied in phosphate buffer and it showed that the smaller MTX/LDH nanoparticles have the longer release time than those of the larger ones.

Key words: layered double hydroxides, alcohol-aqueous coprecipitation method, methotrexatum, nanocompounds, in vitro release