Influence of Cucurbit(n＝7,8)uril on the Solubility and Stability of Chlorambucil
Dong Nan*,1,2 Wang Xiulin2 Pan Jinpin2 Tao Zhu1,2
(1 Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025)
(2 School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025)
Abstract：Theeffects of cucurbit(n＝7,8)uril (Q[7,8]) on the solubility and stability of chlorambucil (CHL) have been investigated. The results from high performance liquid chromatography indicated that in the presence of 2.0×10－4 mol•L－1 Q, there is a 4-fold increase in the stability of chlorambucil at 37 ℃, pH 2.0, while a greater 15-fold increase in the presence of 8.0×10－5 mol•L－1 Q under same conditions. Aqueous solubility of CHL is increased more than 6-fold or 36-fold increase in the presence of 1.0×10－4 mol•L－1 Q or 1.0×10－3 mol•L－1 Q respectively under conditions where degradation is minimized (3 ℃, pH 2.0). Stability constants of the CHL complex with Q[7,8] were determined kinetically and spectrophotometrically under various experimental conditions assuming 1∶1 inclusion complex formation. 1H NMR further confirmed that Q[7,8] could form complexes with CHL and the possible interaction models were proposed.
董南, 王秀林, 盘金品, 陶朱. 七、八元瓜环对抗癌药物苯丁酸氮芥稳定性和溶解度的影响研究[J]. 化学学报, 2011, 69(12): 1431-1437.
DONG Nan, WANG Xiu-Lin, PAN Jin-Pin, TAO Zhu. Influence of Cucurbit(n＝7,8)uril on the Solubility and Stability of Chlorambucil. Acta Chimica Sinica, 2011, 69(12): 1431-1437.