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化学学报
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化学学报 ›› 1994, Vol. 52 ›› Issue (10): 1035-1040. 上一篇    

研究论文

以杯芳烃为基体的仿细胞色素P-450单加氧酶模型的合成

袁立华;陈淑华;赵华明;宁永成   

  1. 四川大学化学系;清华大学化学系
  • 发布日期:1994-10-15

Synthesis of a cytochrome P-450 monooxygenase model compound with calixarene residue

YUAN LIHUA;CHEN SHUHUA;ZHAO HUAMING;NING YONGCHENG   

  • Published:1994-10-15

PDF

417

被引次数

28 | 9

用对叔丁基杯[4]芳烃与卟啉羧酸的酰氯化物反应,并引入金属,合成了杯芳烃-金属卟啉仿细胞色素P-450单加氧酶模型A,A及前体化合物6的结构经IR,^1H NMR,MS和元素分析确定,并确证A中杯环呈"锥体"构象

关键词: 红外分光光度法, 元素分析, 质谱法, 质子磁共振谱法, 细胞色素, 杯芳烃, 金属卟啉, P-450模型

The cytochrome P 450 monooxygenase models I (Q = p-tolyl; M = Zn, MnCl, Co)(II) were prepared from reaction of p-tert-butylcalix[4]arene with 5-p-(4-chlorocarbonylbutoxy)phenyl-10,15,20-tris(p-tolyl)porphyrin followed by inserting of metal ions. The structures of II and their precursor I (M = 2 H) (III) were confirmed by IR, 1H NMR, MS and elemental anal. 1H NMR (500MHz) spectra provide evidence for the "cone" conformation of calixarene residue in III.

Key words: INFRARED SPECTROPHOTOMETRY, ELEMENTAL ANALYSIS, MASS SPECTROGRAPHY, PROTON MAGNETIC RESONANCE SPECTROMETRY, CYTOCHROME, CALIXARENE, METALLOPORPHYRIN

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