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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (1): 143-149. 上一篇    下一篇

研究论文

新型离子型有机锡化合物{[Ph~2Sn]~2[2,6-Py(CO~2)]~3H~2O}^2^-.[HNEt~3]^+~2的合成、表征、性质及晶体结构

尹汉东;王传华;王勇;马春林;邵建新;张军红   

  1. 聊城师范学院化学系;潍坊医学院生化教研室
  • 发布日期:2002-01-15

Synthesis and crystal structure of a novel ionic organotin {[Ph~2Sn]~2[2, 6-Py(CO~2)]~3H~2O}^2^-[HNEt~3]^+~2

YIN HANDONG;WANG CHUANHUA;WANG YONG;MA CHUNLIN;SHAO JIANXIN;ZHANG JUNHONG   

  • Published:2002-01-15

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利用三苯基氯化锡和2,6-吡啶二甲酸在三乙胺存在下以1:1摩尔比反应，合成了离子型有机锡化合物{[Ph~2Sn]~2[2,6-Py(CO~2)]~3H~2O}^2^-[HNEt~3]^+~2。通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征。用X射线单晶衍射测定了该化合物的晶体结构。化合物为单斜晶系，空间群P2~1/n,a=1.7073(7)nm,b=1.7447(7)nm,c=2.5333(10)nm,β=109.694(7)°,Z=4,V=6.824(5)nm^3,D~c=1.282g/cm^3,μ=0.793mm^-^1,F(000)=2696,R~1=0.0563,WR~2=0.1539。化合物中两个锡原子呈七配位畸变五角双锥构型。生物活性测试结果表明，该化合物具有较强的体外抗肿瘤活性。

关键词: 离子, 生物活性, 有机锡化合物, 吡啶二甲酸 P, 合成, 晶体结构

A novel ionic organotin compound {[Ph~2Sn]~2[2, 6-Py(CO~2)]~3H~2O}^2^-[HNEt~3]^+~2 was synthesized by the reaction of Ph~3SnCl with 2, 6-pyridine dicarboxylic acid in 1:1 molar ratio in the presence of an organic base Et~3N. The structure was characterized b elemental analysis, IR and ^1H NMR. The crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to monoclinic with space group P2~1/n, a=1.7073(7) nm, b=1.7447(7) nm, c=2.5333(10) nm, β=109.694(7)°, Z=4, V=6.824(5) nm^3, D~c=1.282 g/cm^3, μ=0.793 mm^-^1, F(000)=2696, R~1=0.0563, WR~2=0.1539. In the crystal structure of the compound, the tin atoms are seven-coordinated in a distorted pengonal bipyramidal geometry. The compound was tested in vitro against human tumour cell lines, MCF-7 and WiDr, and displayed high activity.

Key words: IONS, BIOLOGICAL ACTIVITY, ORGANO TIN COMPOUNDS, PYRIDINEDICARBOXYLIC ACID P, SYNTHESIS, CRYSTAL STRUCTURE

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