The Interaction of Flavonoid-BSA and the Relationship Between Molecular Structure of Flavonoids and Their Binding to BSA
Yang Ran1,3 Zeng Huajin2 Yu Lanlan1 Chen Xiaolan1 Qu Lingbo*,1 Li Ping3
(1 Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
(2 Pharmacy College of Zhengzhou University, Zhengzhou 450052)
(3 Key Laboratory of Modern Chinese Medicine, Ministry of Education, China Pharmaceutical University, Nanjing 210038)
The interactions between eleven flavonoids and BSA were investigated by fluorescence spectroscopy. The binding parameters, including binding constants, binding numbers and binding distance, were calculated. By a comparison of the structures of flavonoids with their binding potency, the structural requirements of flavonoids for the binding were obtained. Furthermore, to explore the effect of molecular structure on the binding, a study on quantitative structure and binding-property relationship (QSPR) was performed on SGI workstations.
杨冉, 曾华金, 于岚岚, 陈晓岚, 屈凌波, 李萍. 黄酮类化合物与牛血清白蛋白的相互作用及构效关系研究[J]. 化学学报, 2010, 68(19): 1995-1999.
YANG Ran, ZENG Hua-Jin, YU Lan-Lan, CHEN Xiao-Lan, QU Ling-Bo, LI Ping. The Interaction of Flavonoid-BSA and the Relationship Between Molecular Structure of Flavonoids and Their Binding to BSA. Acta Chimica Sinica, 2010, 68(19): 1995-1999.