Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (16): 1679-1681.DOI: 10.6023/A12040135 Previous Articles     Next Articles



潘菲a, 施章杰a,b   

  1. a 北京分子科学国家实验室 北京大学化学与分子工程学院 生物有机与分子工程教育部重点实验室 北京 100871;
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 投稿日期:2012-07-30 发布日期:2012-08-15
  • 通讯作者: 施章杰
  • 基金资助:
    项目受科技部973计划(No. 2009CB825300)和国家自然科学基金(Nos. 20925207, 21002001)资助.

Transition Metal-Catalyzed C—H Trifluoromethylation

Pan Feia, Shi Zhangjiea,b   

  1. a Beijing National Laboratory of Molecular Science (BNLMS, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • Received:2012-07-30 Published:2012-08-15
  • Supported by:
    Project supported by the “973” Project from the Ministry of Science and Technology of the People’s Republic of China (No. 2009CB825300) and National Natural Science Foundation of China (Nos. 20925207, 21002001).

In recent years, transition metal-catalyzed C—H trifluoromethylation has been well developed, which is mainly focused on the terminal alkyne C(sp)—H, aromatic and heterocyclic C(sp2)—H and allylic C(sp3)—H trifluoromethylation. This paper briefly overviews the latest developments in this field, the characteristics of various types of reaction, as well as the facing challenges and future direction.

Key words: transition metal, catalysis, trifluoromethylation, C—H activation, directing, cross-coupling