Acta Chim. Sinica ›› 2016, Vol. 74 ›› Issue (2): 149-154.DOI: 10.6023/A15090584 Previous Articles     Next Articles

Review

糖蛋白/糖肽分离富集中的化学

张丽霞, 杜秀芳, 曾盈   

  1. 湖南师范大学化学化工学院化学生物学及中药分析教育部重点实验室 长沙 410081
  • 收稿日期:2015-09-05 出版日期:2016-02-15 发布日期:2015-11-25
  • 通讯作者: 曾盈 E-mail:yingzeng@hunnu.edu.cn
  • 基金资助:

    项目受国家自然科学基金青年项目(No.21205038)和湖南自然科学基金重点项目(No.13JJ2022)资助.

Chemistry in Separation and Enrichment of Glycoproteins/Glycopeptides

Zhang Lixia, Du Xiufang, Zeng Ying   

  1. Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, College of Chemistry and Chemical Engeneering, Hunan Normal University, Changsha 410081
  • Received:2015-09-05 Online:2016-02-15 Published:2015-11-25
  • Supported by:

    Project supported by the National Natural Science Fund of China (No. 21205038) and the Natural Science Foundation of Hunan Province, China (No. 13JJ2022).

Glycoproteins play very important roles in many biological processes. The separation and enrichment of glycoproteins/glycopeptides is still considered a challenging task because of the low abundance and microheterogenity. This review introduces the chemistry method of separation and enrichment of glycoproteins and glycopeptides:hydrozide chemistry, amine chemistry, boronic acid chemistry, beta-elimination and Michael addition chemistry.

Key words: glycoprotein, separation and enrichment, glycoproteomics, chemistry