Acta Chim. Sinica ›› 2019, Vol. 77 ›› Issue (4): 340-350.DOI: 10.6023/A18100414 Previous Articles     Next Articles

Review

口腔癌相关唾液肿瘤生物标志物的分析检测研究进展

金鑫, 王晓英   

  1. 东南大学公共卫生学院 环境医学工程教育部重点实验室 南京 210009
  • 投稿日期:2018-10-07 发布日期:2018-12-05
  • 通讯作者: 王晓英 E-mail:wxy@seu.edu.cn
  • 作者简介:金鑫,东南大学公共卫生学院2017级在读硕士,研究方向为肿瘤相关标志物纳米电化学分析检测研究;王晓英,理学博士,东南大学公共卫生学院副教授,硕士生导师.主要从事肿瘤相关标志物的生物传感与风险评估,食品安全、环境污染相关的纳米电化学分析检测研究.
  • 基金资助:

    项目受国家自然科学基金(Nos.81600179, 81302472)和江苏高校“青蓝工程”资助.

Progress in Analysis and Detection of Salivary Tumor Biomarkers Associated with Oral Cancer

Jin Xin, Wang XiaoYing   

  1. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
  • Received:2018-10-07 Published:2018-12-05
  • Contact: 10.6023/A18100414 E-mail:wxy@seu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81600179, 81302472) and “Blue Project” funded by universities in Jiangsu.

Oral cancer is head and neck cancer, and cancer tissue is located in the oral cavity. The non-invasive early diagnosis is an effective method to reduce the death of the disease. The oral cancer-related substances are first released into the saliva, which is convenient, safe and non-invasive, and is the first choice for screening and early diagnosis of oral cancer. In this paper, the specific types and the commonly used detection methods of the salivary tumor biomarkers at home and abroad were summarized and compared. Specifically, the latest application of new electrochemical biosensor in the detection of the salivary tumor biomarkers associated with oral cancer was mainly described. Futhermore, the summary of its future directions and the potential applications was proposed, which provided reference for the further research and application of the salivary tumor biomarkers in oral cancer.

Key words: oral cancer, saliva, tumor biomarker, detection technology, electrochemical biosensor