Advances in Cyclodextrin Polymers and Their Applications in Biomedicine

doi:10.6023/A20010006

Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (3): 232-244.DOI: 10.6023/A20010006 Previous Articles Next Articles

Review

环糊精聚合物及其生物医学应用的研究进展

郄淑燕^a, 郝莹^b, 刘宗建^a, 王锦^b, 席家宁^a

a 首都医科大学附属北京康复医院北京 100044;
b 中国科学院苏州纳米技术与纳米仿生研究所苏州 215123

投稿日期:2020-01-08 发布日期:2020-02-26
通讯作者: 王锦, 席家宁 E-mail:jwang2014@sinano.ac.cn;xijn888@sina.com
作者简介:郄淑燕,女,主任医师、副教授,首都医科大学附属北京康复医院康复诊疗中心主任,现任中华医学会物理医学与康复学分会康复治疗学组副组长,中国康复医学会康复机构管理专委会常务委员,中国康复医学会运动疗法专业委员会委员、水中运动疗法学组副主委,北京医师协会康复医学专科医师分会常务理事,石景山区重点学科学术带头人.2018年获"北京优秀医师".目前参与科技部重点课题2项,主持省部级课题1项,获省级科技进步奖2次.主编著作1部,主译著作2部,副主编著作和教材4部,以第一或通信作者发表SCI文章5篇,合作发表SCI文章4篇;郝莹,女,副研究员.2013年毕业于苏州大学,获高分子化学与物理专业博士学位,2014年至2017年在美国University of Delaware材料科学与工程系从事博士后研究,2017年8月加入中国科学院苏州纳米所,任副研究员;主要研究方向包括高分子合成化学、功能生物材料以及干细胞定向分化研究;主持国家自然科学基金青年基金1项,发表SCI论文20余篇,获中国发明专利授权3项;刘宗建,男,副研究员.2013年于北京理工大学生命学院获应用化学博士学位,2015年于首都医科大学宣武医院神经生物学博士后出站.现担任首都医科大学附属北京康复医院科研管理部主任、中国电子学会生命电子分会委员、中国老年医学会脑血管分会青年委员.主要研究方向为免疫调控和炎症反应在脑卒中康复的作用机制研究,主持国家自然科学基金面上项目1项和北京市自然科学基金1项,获教育部科技进步奖1项.以第一/通讯作者发表SCI收录论文12篇,EI收录论文2篇;王锦,男,副研究员,硕士生导师.2012年获北京理工大学材料学博士学位,2012年至2014年分别于日本东京工业大学和山形大学从事博士后研究,2014年回国加入中国科学院苏州纳米所任副研究员.主要研究方向为智能超分子水凝胶/气凝胶设计合成及其在生物、能源、环境中的应用,迄今发表SCI论文40余篇,申请发明专利20余项(已授权8项),主持国家自然科学基金3项、江苏省自然科学基金及苏州市科技局等项目近10项,作为主要研究人员参与国家重点研发计划、中国科学院重点部署专项等数10项科研项目;席家宁,男,教授,主任医师,硕士生导师,首都医科大学附属北京康复医院、北京康复医学院院长,首都医科大学康复学系副主任,康复医学与理疗学专业学科带头人.成功带领传统疗养院转型为学院型康复医院,是现代康复医院建设的引领者,"大康复,强综合"康复医院运营管理模式的开拓者和实践者.创立了"以组织系统为基础,以器官功能为核心"的学科架构理论体系,为中国康复医学事业发展做出了突出贡献,荣获"首都劳动奖章".担任中国康复医疗机构联盟主席、中国康复医学会康复机构管理专委会主任委员等.主持多项省部级及以上课题,担任《中国康复科学杂志》主编、《中华临床医师杂志》常务编审等,出版专业著作6部.
基金资助:
项目受国家自然科学基金（Nos.91963124，51773225，51903246）资助.

Advances in Cyclodextrin Polymers and Their Applications in Biomedicine

Qie Shuyan^a, Hao Ying^b, Liu Zongjian^a, Wang Jin^b, Xi Jianing^a

a Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100044;
b Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123

Received:2020-01-08 Published:2020-02-26
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 91963124, 51773225, 51903246).

Cyclodextrins (CDs) are a family of macrocyclic oligosaccharides composed of α-1,4-linked D-glucopyranose units. The most commonly used CDs are α-, β-, and γ-CD, which consist of 6, 7, and 8 D-glucose units, respectively. They possess a relative hydrophobic inner cavity and a hydrophilic outer surface and can form inclusion complexes with various small molecules, metal ions and polymers, tailoring the physicochemical property of the guests, and thus have been widely used in the fields of pharmacy, food, chemistry, chromatography, catalysis, biotechnology, agriculture, cosmetics, hygiene, medicine, textiles and the environment, etc. However, it is difficult to manipulate the native CDs in some specific applications, they are crystallized solid and soluble in water but insoluble in most organic solvents. CD polymers (CDPs), such as crosslinked CDs or CD based hydrogels with various crosslinkers by chemical reactions, and CD based supramolecular polymers formed by physical interactions, can achieve the integration effect and synergy effect of CDs, crosslinkers and guest polymers, not only possessing the inclusion capacity of CDs, but also endowing CDs with other properties introduced by crosslinkers. The CDPs can be easily manipulated and they exhibit unique features that native CDs are lack of. Hence, the design, synthesis and applications of CDPs have attracted broad interests in recent years. This review focuses on the recent progress in CDPs, and different types of CDPs are identified and classified based on the structures and functions, namely CD based polyrotaxane, grafted CDs, crosslinked CDs and linear CDs, etc. Besides, the synthetic methodologies of CDPs are highlighted. Particular attention is paid to the breakthrough on the CDPs in the past five years, and their applications in biomedicine, such as drug delivery, gene delivery, target delivery, controlled release and cell imaging are discussed in detail. The typical applications in other fields such as absorption, environment remediation, thermal insulation, catalysis and slid-ring gels are also discussed in brief. Finally, the review provides brief summary and prospect of CDPs.

Key words: cyclodextrin, polymer, chemical crosslinking, drug carrier, supramolecular self-assembly

Cite this article

Qie Shuyan, Hao Ying, Liu Zongjian, Wang Jin, Xi Jianing. Advances in Cyclodextrin Polymers and Their Applications in Biomedicine[J]. Acta Chimica Sinica, 2020, 78(3): 232-244.

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环糊精聚合物及其生物医学应用的研究进展

Advances in Cyclodextrin Polymers and Their Applications in Biomedicine

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[8]	Zhu Congtan, Yang Ying, Zhao Beikai, Lin Feiyu, Luo Yuan, Ma Shupeng, Zhu Liu, Guo Xueyi. Electrochemical Synthesis of PEDOT and Its Application in Solid-State Dye-sensitized Solar Cells [J]. Acta Chimica Sinica, 2020, 78(10): 1102-1110.
[9]	Mei Pei, Zhang Yuanyuan, Feng Xiao. Amino Acid Functionalized Crystalline Porous Polymers [J]. Acta Chimica Sinica, 2020, 78(10): 1041-1053.
[10]	Kang Shusen, Fan Shaocong, Liu Yan, Wei Yancun, Li Ying, Fang Jingang, Meng Chuizhou. Al-Ion Polymer Solid Electrolyte [J]. Acta Chim. Sinica, 2019, 77(7): 647-652.
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