Acta Chimica Sinica ›› 1990, Vol. 48 ›› Issue (8): 820-824. Previous Articles     Next Articles

Original Articles

硼中子俘获治疗肿瘤的研究 I. 合成硼化核酸的几种化学方法

吕一辛;丁宏勋;吕慧梅   

  1. 中国科学院上海有机化学研究所;南京大学生物化学系
  • 出版日期:1990-08-15 发布日期:1990-08-15

Study on boron neutron capture therapy of tumor I.the chemical methods fro synthesis of boronated nucleic acid

LU YIXIN;DING HONGXUN;LU HUIMEI   

  • Online:1990-08-15 Published:1990-08-15

The methods for coupling of closo-polyhedral boranes with calf thymus DNA and yeast tRNA have been investigated. The functionalized closo-polyhedral boranes Na2B12H11SH, and (Et4N)2B10H9R were synthesized and were subjected to couple with an activated nucleic acid either directly or with a crosslinking agent MBS [m-maleimidobenzoyl)-N-hydroxysuccinimide ester]. The experimental results shows that the method with MBS is a more satisfactory for preparing boronated nucleic acid.

Key words: DEOXYRIBONUCLEIC ACID, NUCLEIC ACIDS, BORON COMPOUNDS, TRANSFER RIBONUCLEIC ACID, SYNTHESIS METHODS, CHEMICAL METHODS, CAGE STRUCTURE, NEUTRON CAPTURE, COUPLING REACTION

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