Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (4): 338-342. Previous Articles     Next Articles

Original Articles

手性环胍衍生物的合成

盛欣,宋伟,陆国元*,王震生   

  1. (南京大学化学系 配位化学国家重点实验室 南京 210093)
  • 收稿日期:2005-06-24 修回日期:2005-10-26 出版日期:2006-02-28 发布日期:2006-02-28
  • 通讯作者: 陆国元

Synthesis of Optically Active Chiral Cyclic Guanidine Derivative

SHENG Xin, SONG Wei, LU Guo-Yuan*, WANG Zheng-Sheng   

  1. (Department of Chemistry, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093)
  • Received:2005-06-24 Revised:2005-10-26 Online:2006-02-28 Published:2006-02-28
  • Contact: LU Guo-Yuan

The optically active chiral bicyclic guanidinium chloride, 4S,8S-bis(hydroxymethyl)-1,5,7-tri- azabicyclo[4.4.0]dec-5-ene hydrochloride was synthesized in ten steps from L-asparagine with a total yield of 2.2%. This pathway aviod usage of virulent thiophosgene and horrible smell organic sulfid.

Key words: guanidine, bicyclic guanidine, chirality, synthesis