DNA: A Biological Target of 23-Oxa-OSW-1?

Acta Chimica Sinica ›› 2008, Vol. 66 ›› Issue (14): 1745-1748. Previous Articles Next Articles

DNA: 23-Oxa-OSW-1生物靶标?

关文a,b 刘玥辉b 申杰b 汤平平b
吴厚铭b 张国安a 曹春阳*,b

(a华中农业大学植物科技学院武汉 430070)
(b中国科学院上海有机化学研究所上海 200032)

投稿日期:2008-01-05 修回日期:2008-03-13 发布日期:2008-07-28
通讯作者: 曹春阳

DNA: A Biological Target of 23-Oxa-OSW-1?

GUAN, Wen ^a,b LIU, Yue-Hui ^b SHEN, Jie ^b TANG, Ping-Ping^b
WU, Hou-Ming ^b ZHANG, Guo-An ^a CAO, Chun-Yang ^*,b

(a Huazhong Agricultural University, Wuhan 430070)
(b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)

Received:2008-01-05 Revised:2008-03-13 Published:2008-07-28
Contact: CAO, Chun-Yang

Abstract

The anticancer drug, steroidal saponin OSW-1 was isolated from the bulbs of Ornithogalum saundersiae. Its analogue 23-Oxa-OSW-1 was found to strongly suppress the growth of the malignant tumor cells with an IC50 0.052～0.4 μmol•L－1, as potent as OSW-1. However its target in vivo is still unknown. In this paper, by using 1D and 2D 1H NMR techniques, it was found that 23-Oxa-OSW-1 could interact with DNA. Further analysis of the NMR data indicated that its xylose part might be involved in its interaction with DNA. In addition, to our knowledge, the detailed assignment of 23-Oxa-OSW-1 1H chemical shifts done here has never been reported so far.

Key words: 23-Oxa-OSW-1, NMR, DNA, xylose

Cite this article

GUAN, Wen ^a,b LIU, Yue-Hui ^b SHEN, Jie ^b TANG, Ping-Ping^b
WU, Hou-Ming ^b ZHANG, Guo-An ^a CAO, Chun-Yang ^*,b. DNA: A Biological Target of 23-Oxa-OSW-1?[J]. Acta Chimica Sinica, 2008, 66(14): 1745-1748.

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DNA: 23-Oxa-OSW-1生物靶标?

DNA: A Biological Target of 23-Oxa-OSW-1?

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