Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (10): 1147-1151. Previous Articles     Next Articles

Original Articles

复合碱性功能单体分子烙印手性固定相

王进防;周良模;王清海;朱道乾;孟子晖   

  1. 中国科学院大连化学物理研究所.大连(116012);中国人民解放军军事医学科学 院六所
  • 出版日期:1999-10-15 发布日期:1999-10-15

Highly efficient molecule imprinting chiral stationary phase utilizing combined basic functional monomers

Wang Jinfang;Zhou Liangmo;Wang Qinghai;Zhu Daoqian;Meng Zihui   

  1. Dalian Inst Chem Phys, CAS.Dalian(116012)
  • Online:1999-10-15 Published:1999-10-15

Molecular imprinting polymers (MIP) against amino acid derivatives utilizing amide plus 2-vinylpyridine as combined basic functional monomers were prepared and evaluated as chiral stationary phase for high-performance liquid chromatography. The MIPs prepared at optimized ratio of the imprinting molecule to combined functional monomers show excellent chiral separation ability to the imprinting enantiomer and its structurally related enantiomers. The effect of chemical group of the analyse on the chiral separation was investigated. Hydrogen bonding and strong ionic interaction between the functional monomer and the analyse were found.

Key words: STATIONARY PHASE, PROPENAMIDE P, PYRIDINE P, HIGH SPEED LIQUID CHROMATOGRAPHY, AMINO ACID

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