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有机化学
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有机化学 ›› 2012, Vol. ›› Issue (03): 612-615.DOI: 10.6023/cjoc1108072 上一篇    下一篇

研究简报

无溶剂条件下简单、有效地合成1,6-二氢嘧啶-6-酮衍生物

刘丽华a, 殷姗b, 夏盛b, 蔡佩君a, 荣良策a,b   

  1. a 中国矿业大学化工学院 徐州 221008;
    b 徐州师范大学化学化工学院 徐州 221116
  • 收稿日期:2011-08-07 修回日期:2011-10-22 发布日期:2012-03-24
  • 通讯作者: 蔡佩君, 荣良策 E-mail:lcrong@xznu.edu.cn; lcrong2005@yahoo.com
  • 基金资助:

    江苏省高校自然科学基础研究基金(No. 08KJB150017)及徐州师范大学科研平台(No. 10XLS02)资助项目.

A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions

Liu Lihuaa, Yin Shanb, Xia Shengb, Cai Peijuna, Rong Liangcea,b   

  1. a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116
  • Received:2011-08-07 Revised:2011-10-22 Published:2012-03-24
  • Supported by:

    Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Research Platform Foundation of Xuzhou Normal University (No. 10XLS02).

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被引次数

5

以芳醛、氰乙酸乙酯和碳酸胍为原料, 氢氧化钠-碳酸钾为催化剂, 在无溶剂条件下70 ℃反应有效地合成了1,6-二氢嘧啶-6-酮衍生物, 本方法具有反应时间短、条件温和、处理简单和环境友好等优点. 通过红外、核磁、高分辨质谱和晶体的X 衍射确定产物的结构.

关键词: 1,6-二氢-6-嘧啶酮, 杂环化合物, 无溶剂反应

An efficient and facile synthesis of 2-amino-1,6-dihydro-6-oxo-pyrimidine derivatives via reaction of aromatic aldehydes, ethyl 2-cyanoacetate and guanidine carbonate by using NaOH and K2CO3 as catalyst under solvent-free conditions at about 70 ℃ is reported. This protocol has the advantages of shorter time, mild conditions, easy work-up and environmental friendliness. The products were identified by IR, 1H NMR and HRMS techniques, and that of 4e was additionally confirmed by X-ray diffraction analysis.

Key words: 6-oxo-pyrimidine, heterocyclic compound, solvent-free reaction