有机化学 ›› 2018, Vol. 38 ›› Issue (5): 1155-1164.DOI: 10.6023/cjoc201709049 上一篇    下一篇

研究论文

水相催化3,5-二烷基-4-硝基异噁唑与三氟甲基酮的亲核加成反应

王晶晶, 李峰, 徐妍, 王娟, 武紫燕, 杨成玉, 刘澜涛   

  1. 商丘师范学院化学化工学院 药物绿色合成河南省工程实验室 商丘 476000
  • 收稿日期:2017-09-29 修回日期:2017-12-29 出版日期:2018-05-25 发布日期:2018-01-26
  • 通讯作者: 王晶晶,E-mail:wangjingjing0918@163.com;刘澜涛,E-mail:liult05@iccas.ac.cn E-mail:wangjingjing0918@163.com;liult05@iccas.ac.cn
  • 基金资助:

    国家自然科学基金(Nos.21402116,21502111,21572126)、河南省重点科技攻关项目(No.172102210099)和河南省高等学校重点科研(No.15A150072)资助项目.

Catalytic Nucleophilic Addition of 3, 5-Dialkyl-4-nitroisoxazoles to Trifluoromethyl Ketones on Water

Wang Jingjing, Li Feng, Xu Yan, Wang Juan, Wu Ziyan, Yang Chengyu, Liu Lantao   

  1. Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000
  • Received:2017-09-29 Revised:2017-12-29 Online:2018-05-25 Published:2018-01-26
  • Contact: 10.6023/cjoc201709049 E-mail:wangjingjing0918@163.com;liult05@iccas.ac.cn
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (Nos. 21402116, 21502111, 21572126), the Key Scientific and Technological Project of Henan Province (No. 172102210099) and the Key Science Research of Education Committee in Henan Province (No. 15A150072).

研究了水相三乙胺催化3,5-二烷基-4-硝基异噁唑与三氟甲基酮的亲核加成反应,以66%~99%的产率合成了一系列三氟甲基叔醇衍生物.通过脱水或氧化反应可有效的将目标产物转化为烯烃或羧酸类化合物.

关键词: 水相, 亲核加成, 3,5-二烷基-4-硝基异噁唑, 三氟甲基酮

The triethylamine catalyzed nucleophilic addition of 3, 5-dialkyl-4-nitroisoxazoles to trifluoromethyl ketones on water has been realized affording trifluoromethyl tertiary alcohol derivatives in 66%~99% yields. The products were easily transformed to the resulting alkenes by dehydration or acids by oxidation.

Key words: on water, nucleophilic addition, 3, 5-dialkyl-4-nitroisoxazoles, trifluoromethyl ketones References