有机化学 ›› 2018, Vol. 38 ›› Issue (7): 1837-1841.DOI: 10.6023/cjoc201801047 上一篇    下一篇

研究简报

爪哇毛霉脂肪酶催化合成2-氨基噻吩衍生物

卢粤, 姜国芳, 谢宗波, 陈国庆, 乐长高   

  1. 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2018-01-30 修回日期:2018-03-17 发布日期:2018-04-04
  • 通讯作者: 姜国芳, 乐长高 E-mail:zhgle@ecit.cn;zbxie@ecit.cn
  • 基金资助:

    国家自然科学基金(Nos.21462001,21262002,21465002)、江西省科技计划(No.20161BCB24006)、江西省教育厅科技(Nos.KJLD14050,GJJ150584)资助项目.

Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

Lu Yue, Jiang Guofang, Xie Zongbo, Chen Guoqing, Le Zhanggao   

  1. Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2018-01-30 Revised:2018-03-17 Published:2018-04-04
  • Contact: 10.6023/cjoc201801047 E-mail:zhgle@ecit.cn;zbxie@ecit.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21262002, 21465002), the Science and Technology Projects of Jiangxi Province (No. 20161BCB24006), the Science and Technology Foundation of the Jiangxi Provincial Education Department (Nos. KJLD14050, GJJ150584).

α-活性亚甲基腈和2,5-二羟基-1,4-二噻烷为原料,通过爪哇毛霉脂肪酶催化的Gewald反应合成了一系列2-氨基噻吩类化合物.该方法与传统的化学催化方法相比,具有反应条件温和、催化剂可生物降解、底物适用范围较宽泛等优点.

关键词: α-活性亚甲基腈, 2,5-二羟基-1,4-二噻烷, 脂肪酶, Gewald反应, 2-氨基噻吩

A series of 2-aminothiophene derivatives were synthesized by the Gewald reaction between α-active methylene nitrilthes and 2,5-dihydroxy-1,4-dithiane using amano lipase M from Mucor javanicus as biocatalyst. The method has the advantages of mild reaction conditions, biodegradability of catalyst and wide range of substrates compared with traditional catalysts.

Key words: α-active methylene nitrile, 2,5-dihydroxy-1,4-dithiane, lipase, Gewald reaction, 2-aminothiophene