有机化学 ›› 2018, Vol. 38 ›› Issue (11): 3032-3038.DOI: 10.6023/cjoc201803025 上一篇    下一篇

所属专题: 元素有机化学合辑2018-2019 有机小分子-金属协同催化

研究论文

钯/乙酸亚铜共同促进的嘧啶硫醚的脱硫碳碳偶联反应

刘伯渠a, 燕中飞b, 权正军b   

  1. a 甘肃民族师范学院化学与生命科学系 合作 747000;
    b 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2018-03-17 修回日期:2018-05-10 发布日期:2018-07-16
  • 通讯作者: 权正军 E-mail:quanzj@nwnu.edu.cn
  • 基金资助:

    西北师范大学科研创新基金(No.NWNU-LKQN-15-1)资助项目.

Palladium/Copper(I) Acetate-Promoted Desulfurative Coupling of Pyrimidine Thioether with Alkynes or Arylboronic Acids

Liu Boqua, Yan Zhongfeib, Quan Zhengjunb   

  1. a Department of Chemistry and Life Science, Gansu Normail University for Nationalities, Hezuo 747000;
    b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2018-03-17 Revised:2018-05-10 Published:2018-07-16
  • Supported by:

    Project supported by the Scientific and Technological Innovation Engineering Program of Northwest Normal University (No. NWNU-LKQN-15-1).

报道了一种钯催化、乙酸亚铜盐促进的嘧啶硫醚/喹啉硫醚与炔烃或芳基硼酸的脱硫碳碳偶联反应,合成了一系列2-炔基嘧啶和2-芳基嘧啶/喹啉衍生物,产率良好(64%~87%).所用的乙酸亚铜盐廉价、稳定,反应产率高,底物适用范围较广.

关键词: 嘧啶硫醚, 嘧啶衍生物, Liebeskind-Srogl反应, 炔烃, 芳基硼酸

An efficient method for carbon-carbon bond formation via desulfurative coupling of pyrimidine thioethers/4-phenylquinoline thioethers with alkynes or arylboronic acids is described. The reaction was promoted by a cheap and stable copper salt[copper(I) acetate] and catalyzed by palladium with good yields and wild substrate scope.

Key words: pyrimidine thioether, pyrimidine derivative, Liebeskind-Srogl reaction, alkyne, arylboronic acid