镍氢催化对映选择性氢胺化反应合成手性芳基胺、烷基胺和酰胺

doi:10.6023/cjoc202100097

有机化学 ›› 2021, Vol. 41 ›› Issue (12): 4846-4848.DOI: 10.6023/cjoc202100097 上一篇

所属专题：镍催化有机反应虚拟合辑；绿色合成化学专辑

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镍氢催化对映选择性氢胺化反应合成手性芳基胺、烷基胺和酰胺

孔令恒, 李兴伟^*()

陕西师范大学化学化工学院胶体与界面化学教育部重点实验室西安 710062

发布日期:2021-12-01
通讯作者: 李兴伟

NiH-Catalyzed Enantioselective Hydroamination to Synthesize Chiral Arylamines, Alkylamines and Amides

Lingheng Kong, Xingwei Li()

Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062

Published:2021-12-01
Contact: Xingwei Li

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孔令恒, 李兴伟. 镍氢催化对映选择性氢胺化反应合成手性芳基胺、烷基胺和酰胺[J]. 有机化学, 2021, 41(12): 4846-4848.

Lingheng Kong, Xingwei Li. NiH-Catalyzed Enantioselective Hydroamination to Synthesize Chiral Arylamines, Alkylamines and Amides[J]. Chinese Journal of Organic Chemistry, 2021, 41(12): 4846-4848.

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图/表 4

图1. NiH催化C—C键构建

Figure 1. The construction of C—C bond by NiH catalysis

图2. NiH催化对映选择性氢胺化

Figure 2. Enantioselective NiH-catalyzed hydroamination

表1. 部分底物拓展

Table 1. Part of the substrate scope

图3. 机理实验

Figure 3. Mechanistic experiments

参考文献 8

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镍氢催化对映选择性氢胺化反应合成手性芳基胺、烷基胺和酰胺

NiH-Catalyzed Enantioselective Hydroamination to Synthesize Chiral Arylamines, Alkylamines and Amides

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