有机化学 ›› 2014, Vol. 34 ›› Issue (1): 92-106.DOI: 10.6023/cjoc201307021 上一篇    下一篇

综述与进展

双-1,2,3-三唑化合物的合成与应用研究进展

霍景沛a,b, 韦新平a, 莫广珍a, 彭湃a, 钟铭丽a, 陈任宏c, 汪朝阳a   

  1. a 华南师范大学化学与环境学院 教育部环境理论化学重点实验室 广州 510006;
    b 华南理工大学化工学院 广州 510630;
    c 广东食品药品职业学院 广州 510520
  • 收稿日期:2013-07-15 修回日期:2013-08-30 出版日期:2014-01-25 发布日期:2013-09-06
  • 通讯作者: 汪朝阳 E-mail:wangzy@scnu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 20772035);广东省高等学校人才引进专项资金(No. 粤财教[2011]431号);广东省自然科学基金(No. S2011010001556)资助项目.

Progresses in Syntheses and Applications of Bis-1,2,3-triazoles

Huo Jingpeia,b, Wei Xinpinga, Mo Guangzhena, Peng Paia, Zhong Minglia, Chen Renhongc, Wang Zhaoyanga   

  1. a Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006;
    b School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510630;
    c Guangdong Food and Drug Vocational College, Guangzhou 510520
  • Received:2013-07-15 Revised:2013-08-30 Online:2014-01-25 Published:2013-09-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20772035), the 3rd Talents Special Funds of Guangdong Higher Education (No. Guangdong-Finance-Education [2011]431) and the Natural Science Foundation of Guangdong Province (No. S2011010001556).

双-1,2,3-三唑化合物作为重要的N-杂环化合物,近年来吸引了越来越多不同领域化学家的关注. 为了合成对称的与不对称的双三唑,一些合成中的新发现、新策略、新技术不断涌现. 从所用原料与合成方式等角度,可分为Click反应-氧化偶联法、原料组合法、浓度控制法、基团活性差异法、基团保护法、控制投料比法、特殊试剂法等. 同时,介绍了相关双三唑化合物在药物化学、配位化学、化学传感器、分子识别、生物化学、超分子化学、表面活性剂等应用领域的新进展,并对双三唑化合物的合成与应用前景进行了展望.

关键词: 双-1,2,3-三唑, 合成, Click反应, 叠氮化物, 炔烃, 进展

As a kind of important N-heterocyclic compounds, bis-1,2,3-triazoles have drawn more and more interest of chemists in different research territories. In order to synthesize symmetric and unsymmetrical bis-1,2,3-triazoles, many synthetic strategies, methods and techniques, such as click reaction-oxidative coupling, the combination of starting materials, the concentration control method, the utilization of different active groups, the protection technique, the control of feed ratio, the use of special reagents, and so on, have been developed recently. Classified as different substrates and synthetic approaches, these research progresses are summarized. At the same time, the new progresses in the applications of bis-1,2,3-triazoles in different fields, including medicinal chemistry, coordination chemistry, chemical sensor, molecular recognition, biochemistry, supramolecular chemistry and surfactant are also mentioned in this review. It is pointed out that how to cleverly design and efficiently synthesize the novel bis-1,2,3-triazoles for some special purpose via the simple general methods is still a great challenge.

Key words: bis-1,2,3-triazoles, synthesis, click reaction, azides, alkynes, progress