单氟甲基化反应的研究进展

doi:10.6023/cjoc202003055

摘要/Abstract

有机氟化物在医药、农业化学等领域发挥着不可缺少的作用，其中，氟甲基官能团具有较强的的亲脂性，可以极大地改善药物分子的药代动力学性质.因此，开发各类氟化反应具有重要的价值，尤其向分子中引入单氟甲基在氟化学领域备受关注.针对不同结构分子的单氟甲基化，按照氟甲基试剂分类总结单氟甲基化反应的研究进展，并对部分反应可能的机理进行讨论.

关键词: 有机氟化物, 氟甲基官能团, 氟甲基试剂, 单氟甲基化反应

Organic fluorides play an indispensable role in medicine, agricultural chemistry and other fields, among them fluoromethyl functional groups have strong lipophilicity, which can greatly improve the pharmacokinetics properties of drug molecules. Therefore, it is of great value to develop various fluorination reactions, especially to introduce monofluoromethyl into molecules in fluorination chemistry. The research progress of the monofluoromethylation of different structural molecules is summarized according to the classification of fluoromethyl reagents, and the possible mechanism of some reactions is discussed.

Key words: organic fluoride, fluoromethyl functional group, fluoromethyl reagent, monofluoromethylation reaction

引用此文

刘颖杰, 李晨, 孟建萍, 宋冬雪, 刘冰, 许颖. 单氟甲基化反应的研究进展[J]. 有机化学, 2020, 40(8): 2322-2337.

Liu Yingjie, Li Chen, Meng Jianping, Song Dongxue, Liu Bing, Xu Ying. Recent Progress in Monofluoromethylation[J]. Chinese Journal of Organic Chemistry, 2020, 40(8): 2322-2337.

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