小盘木中多样性二萜类化合物

doi:10.6023/cjoc202005060

有机化学 ›› 2020, Vol. 40 ›› Issue (9): 2811-2816.DOI: 10.6023/cjoc202005060 上一篇下一篇

研究论文

小盘木中多样性二萜类化合物

韩光辉^a,b, 任宇豪^b, 范耀月^b, 纪开龙^b, 周彬^b, 曹卫国^a, 岳建民^b

a 上海大学理学院化学系上海 200444;
b 中国科学院上海药物研究所新药研究国家重点实验室上海 201203

收稿日期:2020-05-22 修回日期:2020-06-16 发布日期:2020-07-01
通讯作者: 曹卫国, 岳建民 E-mail:wgcao@staff.shu.edu.cn;jmyue@simm.ac.cn
基金资助:
国家自然科学基金（Nos.21532007，21772213）、国家重大新药创制专项（No.2018ZX09711001-001-005）、中国科学院战略生物资源计划（No.KFJ-BRP-008）及中国科学院青年创新促进会资助项目.

Diverse Diterpenoids from Microdesmis casearifolia

Han Guanghui^a,b, Ren Yuhao^b, Fan Yaoyue^b, Ji Kailong^b, Zhou Bin^b, Cao Weiguo^a, Yue Jianmin^b

a Department of Chemistry, College of Science, Shanghai University, Shanghai 200444;
b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received:2020-05-22 Revised:2020-06-16 Published:2020-07-01
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21532007, 21772213), the Drug Innovation Major Project of China (No. 2018ZX09711001-001-005), the Biological Resources Program of Chinese Academy of Sciences (No. KFJ-BRP-008) and the Youth Innovation Promotion Association, Chinese Academy of Sciences.

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摘要/Abstract

从小盘木植物中分离鉴定了四个新二萜类化合物1~4，分别属于dolabrane烷型、玫瑰烷型、半日花烷型以及烟草烷型.综合利用各种光谱数据阐明了四个二萜类化合物的相对立体结构，并通过圆二色谱（ECD）数据确定了它们的绝对构型.

关键词: 小盘木, 小盘木属, 二萜化合物, 小盘木素A~D, 结构解析, 圆二色谱(ECD)分析

Four new diterpenoids, casearoids A~D (1~4), including dolabrane, orosane, labdane, and cembrane, were isolated and characterized from Microdesmis casearifolia. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of these diterpenoids were established by analysis of the electronic circular dichroism (ECD) data.

Key words: Microdesmis casearifolia, Microdesmis genus, diterpenoid, casearoids A~D, spectroscopic analysis, electronic circular dichroism (ECD) analysis

引用此文

韩光辉, 任宇豪, 范耀月, 纪开龙, 周彬, 曹卫国, 岳建民. 小盘木中多样性二萜类化合物[J]. 有机化学, 2020, 40(9): 2811-2816.

Han Guanghui, Ren Yuhao, Fan Yaoyue, Ji Kailong, Zhou Bin, Cao Weiguo, Yue Jianmin. Diverse Diterpenoids from Microdesmis casearifolia[J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2811-2816.

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小盘木中多样性二萜类化合物

Diverse Diterpenoids from Microdesmis casearifolia

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