Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (02): 349-353 .DOI: 10.6023/cjoc1106032 Previous Articles     Next Articles



侯淑华a,b, 刘武军a, 赵宗保a   

  1. a 中国科学院大连化学物理研究所生物技术部 大连 116023;
    b 中国科学院研究生院 北京 100049
  • 收稿日期:2011-06-03 修回日期:2011-09-22 发布日期:2012-03-09
  • 通讯作者: 赵宗保

Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities

Hou Shuhuaa,b, Liu Wujuna, Zhao Zongbaoa   

  1. a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023;
    b Graduate University of Chinese Academy of Sciences, Beijing 100049
  • Received:2011-06-03 Revised:2011-09-22 Published:2012-03-09

Four methods were tested to synthesize nicotinamide adenine dinucleotide (NAD) analogs, and 5 NAD analogs were prepared. Assays of these NAD analogs indicated that malic enzyme and alcohol dehydrogenase had about 13%~30% enzymatic activity in the presence of analog 3b or 3d, whereas significantly lower activities were observed in the presence of analog 3a, 3c or 3e.

Key words: NAD analog, pyrophosphate, bioactivity, alcohol dehydrogenase