Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (10): 1846-1863.DOI: 10.6023/cjoc1201142 Previous Articles     Next Articles

Reviews

巯基-烯/炔点击化学研究进展

刘清, 张秋禹, 陈少杰, 周健, 雷星锋   

  1. 西北工业大学理学院应用化学系 教育部空间物理与化学重点实验室 西安 710129
  • 收稿日期:2012-01-14 修回日期:2012-04-13 出版日期:2012-10-25 发布日期:2012-05-18
  • 通讯作者: 张秋禹 E-mail:qyzhang@nwpu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 51173146/E030904)和国家重点基础研究发展规划(973计划)(No. 2010CB635111)资助项目.

Progress in Thiol-Ene/Yne Click Chemistry

Liu Qing, Zhang Qiuyu, Chen Shaojie, Zhou Jian, Lei Xingfeng   

  1. Key Laboratory of Applied Physics and Chemistry of Ministry of Education, Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an 710072
  • Received:2012-01-14 Revised:2012-04-13 Online:2012-10-25 Published:2012-05-18
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 51173146/E030904) and the Major State Basic Research Development Program of China (973 Program) (No. 2010CB635111).

Click chemistry has attracted great interests due to a wide variety of superior merits, including a wide range of applications, simplified experimental condition, rapid reaction speed, higher functional group conversion, environmental friendly and selectivity. And conception of click chemistry contributed to the synthetic chemistry apparently, in particular, with respect to pharmaceutical manufacture and biomedical materials, resulting in the most useful and promising synthetic method. Furthermore, thiol-ene/yne click chemistry, utilizing inclusion of visible light or UV light as catalytic medium, is a comparatively novel kind of click chemistry in comparison to several types of conventional reactions. In addition, the properties of the creative reaction stems from the combination the photoinitiated chemical reaction with the forementioned traditional click chemistry, providing a flexible approach to occur reaction within the oriented region and functional group. This review highlights the recent research on the preparation of functional polymeric microsphere, amphipathic block well-defined polymer, materials employed in the molecular device, desired dendritic polymers and chemistry modification via thiol-ene/yne click chemistry. Moreover, the problems and solutions are given for the future development of thiol-ene/yne click chemistry.

Key words: click chemistry, thiol-ene/yne, functional polymeric microsphere, amphipathic block polymer, molecular device, dendritic polymers, surface modification