Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2018-2039.DOI: 10.6023/cjoc201205026 Previous Articles     Next Articles



王勇, 程国林, 崔秀灵   

  1. 分子药物教育部工程研究中心 厦门市海洋与基因工程药物重点实验室 华侨大学生物医学学院、分子药物研究院 厦门 361021
  • 收稿日期:2012-05-21 修回日期:2012-06-26 发布日期:2012-07-02
  • 通讯作者: 崔秀灵
  • 基金资助:

    福建省闽江学者计划(No. 10BS216)、厦门市科技计划项目(No. 3502z20101014)、华侨大学基本科研业务基金(Nos. JB-GJ1008, 11BS424)资助项目.

Easily Modified Directing Groups for the Palladium-Catalyzed C—H Functionalization

Wang Yong, Cheng Guolin, Cui Xiuling   

  1. Engineering Research Center of Molecular Medicine, Ministry of Education; Xiamen Key Laboratory of Marine and Gene Drugs; School of Biomedical Sciences, Institutes of Molecular Medicine, Huaqiao University, Xiamen 361021
  • Received:2012-05-21 Revised:2012-06-26 Published:2012-07-02
  • Supported by:

    Project supported by the Minjiang Scholar Program (No. 10BS216), the Xiamen Scientific and Technology Foundation (No. 3502z20101014), the Basic Scientific Research Fund of Huaqiao University (Nos. JB-GJ1008, 11BS424).

Palladium-catalyzed C—H functionalization is one of the hot topics in the field of organic synthesis methodology. Directing groups play an important role in the regioselectivity of C—H activation. Herein, this review presents the recent progress on the removable and transformable directing groups for the palladium-catalyzed C—H bonds activation and their applications in the synthesis of complicate molecules. Moreover, the research trend of this area is also prospected.

Key words: C—H functionalization, palladium catalyzed, directing groups, regioselectivity