Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2090-2094.DOI: 10.6023/cjoc201210029 Previous Articles     Next Articles



张艳a,b, 朱成建b   

  1. a 江南大学医药学院 无锡 214122;
    b 南京大学化学化工学院 南京 210093
  • 收稿日期:2012-10-17 修回日期:2012-10-29 发布日期:2012-10-31
  • 通讯作者: 张艳
  • 基金资助:

    国家自然科学基金(No. 21074054)和2012江苏省大学生创新训练资助项目.

Oxidative Cross Coupling of sp3-C—H Bonds Catalyzed by Bu4NAuCl4 with H2O2 as Oxidant

Zhang Yana,b, Zhu Chengjianb   

  1. a School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122;
    b State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093
  • Received:2012-10-17 Revised:2012-10-29 Published:2012-10-31
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21074054) and the Innovation Experiment Program for University Students of Jiangsu Province.

Activation of two sp3-C—H bonds and oxidative alkylation of sp3-C—H bond adjacent to a nitrogen atom of tertiary amine were catalyzed by Bu4NAuCl4 with H2O2 as oxidant under mild reaction conditions. The safe, convenient, and environmentally benign process, as well as the broad substrate scope, low catalyst loading, high selectivity, short reaction time, and good yields make the protocol very practical.

Key words: sp3-C—H activation, cross-dehydrogenative coupling, oxidative alkylation, gold catalyst