Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2099-2107.DOI: 10.6023/cjoc202004028 Previous Articles     Next Articles


王慧, 王安玮, 夏珍珍, 周维友, 孙中华, 钱俊峰, 何明阳   

  1. 常州大学石油化工学院 江苏省绿色催化材料与技术重点实验室 江苏常州 213164
  • 收稿日期:2020-04-18 修回日期:2020-05-04 发布日期:2020-05-15
  • 通讯作者: 周维友
  • 基金资助:

Nickel(Ⅱ)-Catalyzed Aerobic Cross-Dehydrogenative Coupling for the Synthesis of N-Aryl Tetrahydroisoquinolines

Wang Hui, Wang Anwei, Xia Zhenzhen, Zhou Weiyou, Sun Zhonghua, Qian Junfeng, He Mingyang   

  1. Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164
  • Received:2020-04-18 Revised:2020-05-04 Published:2020-05-15
  • Supported by:
    Project supported by the Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology (No. BM2012110), the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX19_1746), and the Natural Science Foundation of Jiangsu Province (No. BK20181461).

An nickel-catalyzed aerobic cross-dehydrogenative coupling of N-aryl tetrahydroisoquinolines is presented. The catalytic system could tolerate various N-aryl tetrahydroquinoline derivatives and nucleophiles, and the target products could be obtained in good to excellent yields. Compared with reported methods, the protocol uses molecular oxygen as a sustainable oxidant, and provides an effective approach to the synthesis of tetrahydroisoquinoline derivatives under mild and practical conditions.

Key words: cross-dehydrogenative coupling, C-H activation, nickel, molecular oxygen, N-aryl tetrahydroisoquinoline