Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1244-1253.DOI: 10.6023/cjoc201302013 Previous Articles     Next Articles



杨阳a, 陈洁君b, 张大勇a, 董晓芳a, 赵长琦a   

  1. a 细胞增殖及调控生物学教育部重点实验室 基因工程药物及生物技术北京市重点实验室 北京师范大学生命科学学院 北京 100875;
    b 科技部中国生物技术发展中心 生物资源与安全处 北京 100039
  • 收稿日期:2013-02-17 修回日期:2013-03-29 发布日期:2013-04-09
  • 通讯作者: 赵长琦
  • 基金资助:

    十二五“重大新药创制”科技重大专项(No.2013ZX09103001-019-001)和国家重点基础研究发展计划(973计划, No.2007CB10680002)资助项目.

Chemical Constituent and Biological Activities of the Genus Iris

Yang Yanga, Chen Jiejunb, Zhang Dayonga, Dong Xiaofanga, Zhao Changqia   

  1. a Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Key Laboratory of Gene Engineering Drugs & Biological Technology, College of Life Science, Beijing Normal University, Beijing 100875;
    b Biosource and Biosafety Division China National Center for Biotechnology Development, Ministry of Science and Technology, Beijing 100039
  • Received:2013-02-17 Revised:2013-03-29 Published:2013-04-09
  • Supported by:

    Project supported by the Twelfth Five-Year Plan "Essential Drug Research and Development" Major Projects of Science and Technology (No.2013ZX09103001-019-001) and the National Basic Research Program of China (973 program, No.2007CB10680002)

Species of the genus Iris (Iridaceae) have a long history of traditional medicinal use in many places of the world, and are used in the treatment of cancer, inflammation, bacterial and viral infections. Iris plants have been previously recognized as rich sources of secondary metabolites, which mainly belong to flavonoids, triterpenoids, benzoquinones and stilbenes.As the predominant component, flavonoids have been frequently reported.This paper describes 65 triterpenoids including iridals which is a kind of unusual triterpenoids isolated from various Iris species, 21 benzoquinones and 9 stilbenes from 21 Iris species since 1982, and the details of their source, structure are given.And the possible biogenetic ways of iridals are also presented.Moreover, many of these compounds exhibited anticancer, antimalarial, ecdysteroid antagonist, antioxidant, enzyme inhibitor, antiulcer properties.

Key words: Iris, triterpenoids, biogenetic ways, benzoquinones, stilbenes, biological activity