Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1235-1243.DOI: 10.6023/cjoc201303044 Previous Articles     Next Articles

Reviews

达菲合成最新进展

张田财, 鲁慧, 张辅民, 程军, 刘天阳   

  1. 兰州大学功能有机分子化学国家重点实验室 兰州大学化学化工学院 兰州 730000
  • 收稿日期:2013-03-27 修回日期:2013-05-09 发布日期:2013-05-13
  • 通讯作者: 张辅民 E-mail:zhangfm@lzu.edu.cn
  • 基金资助:

    国家自然科学基金委(Nos.20972059, 21290180);教育部长江学者创新团队(No.IRT1138)和中央高校基本科研费(No.lzujbky-2013-ct02)资助项目.

Recent Progress in the Synthesis of Tamiflu

Zhang Tiancai, Lu Hui, Zhang Fu-Min, Cheng Jun, Liu Tianyang   

  1. State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000
  • Received:2013-03-27 Revised:2013-05-09 Published:2013-05-13
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.20972059, 21290180), the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1138) and the Fundamental Research Funds for the Central Universities (No.lzujbky-2013-ct02).

Tamiflu, one of the most common orally drugs for the treatment and prevention of influenza, has attracted extensive interests of synthetic chemists all over the world.Concise, efficient, and scalable synthetic approaches toward this molecule have been a very active field in recent years, and many diverse synthetic routes have been developed to date.In this review, representative synthetic routes employing chiral starting material or catalytic asymmetric reactions are briefly summarized.

Key words: tamiflu, drug, total synthesis