Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (2): 355-361.DOI: 10.6023/cjoc201307022 Previous Articles     Next Articles



王宏雁, 杨亮茹, 肖咏梅, 毛璞, 朱晓亮, 袁金伟, 屈凌波   

  1. 河南工业大学化学化工学院 郑州 450001
  • 收稿日期:2013-07-15 修回日期:2013-09-25 发布日期:2013-10-25
  • 通讯作者: 肖咏梅
  • 基金资助:


Synthesis of Novel Fatty Amide Analogues of Troxerutin Catalyzed by Lipase in Organic Medium

Wang Hongyan, Yang Liangru, Xiao Yongmei, Mao Pu, Zhu Xiaoliang, Yuan Jinwei, Qu Lingbo   

  1. College of Chemistry & Chemical engineering, Henan University of Technology, Zhengzhou 450001
  • Received:2013-07-15 Revised:2013-09-25 Published:2013-10-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172055).

In nonaqueous medium, a series of troxerutin amidation analogues were synthesized by the reaction of vinyl-troxerutin esters with fatty amines. The influence parameters including enzyme source, the amount of the enzyme, reactive medium, water content of solvents and reaction time were investigated. The results showed that the amidation occurred regioselectively at vinyl-ester bond. Using pyridine as solvent (water content <1%), the amidation reaction catalyzed by lipase LS-10 (20 mg/mL) reached plateau after 21 h at 50 ℃.

Key words: amidation, troxerutin, enzymatic synthesis, fatty amine, regioselectivity