Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (2): 409-420.DOI: 10.6023/cjoc202309011 Previous Articles     Next Articles



黄净a,b, 杨毅华b, 张占辉a,*(), 刘守信b,*()   

  1. a 河北师范大学化学与材料科学学院 石家庄 050024
    b 河北科技大学 河北省新药创制协同创新中心 河北省药用分子化学重点实验室 石家庄 050018
  • 收稿日期:2023-09-11 修回日期:2023-10-23 发布日期:2023-10-30
  • 基金资助:
    “973”计划前期研究专项课题(2011CB512007); “973”计划前期研究专项课题(2012CB723501); 国家自然科学基金(30472074); 国家自然科学基金(30873139); 国家自然科学基金(21978067)

Recent Progress on Green Methods and Technologies for Efficient Formation of Amide Bonds

Jing Huanga,b, Yihua Yangb, Zhanhui Zhanga(), Shouxin Liub()   

  1. a College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024
    b Hebei Key Laboratory of Molecular Chemistry for Drug, Hebei Collaborative Innovation Center of New Drug Creation, Hebei University of Science & Technology, Shijiazhuang 050018
  • Received:2023-09-11 Revised:2023-10-23 Published:2023-10-30
  • Contact: E-mail:;
  • Supported by:
    National Basic Research Program of China(2011CB512007); National Basic Research Program of China(2012CB723501); National Natural Science Foundation of China(30472074); National Natural Science Foundation of China(30873139); National Natural Science Foundation of China(21978067)

Amide bond constructions are crucial in peptide synthesis and pharmaceutical chemistry research. The traditional methods of peptide synthesis require the use of excessive amounts reagents and solvents, posing a threat to the environment and human health. It is still the current research focus to develop environmentally friendly novel acylation reagents and efficient, green, and sustainable amide bond synthesis methods. From the green chemistry’s principles, this paper is focused on the efficient formation of amide bonds in peptide, including the catalysis of elemental organic chemicals, some green solvents and reagents, and some physical strengthening methods, etc. The application of these methods and technologies was also discussed in peptide chemistry.

Key words: amidation, catalysis, green chemistry, peptide