Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (1): 36-53.DOI: 10.6023/cjoc201308012 Previous Articles     Next Articles



张巍, 张家慧, 刘运奎   

  1. 浙江工业大学化学工程与材料学院 绿色化学技术国家重点实验室培育基地 杭州 310014
  • 收稿日期:2013-08-10 修回日期:2013-09-26 发布日期:2013-09-30
  • 通讯作者: 刘运奎
  • 基金资助:

    国家自然科学基金(No. 21172197);浙江省自然科学基金(No. Y4100201)和浙江省科技厅(No. 2011R09002-09)资助项目.

Recent Advances in C—H Functionalizations Assisted by Removable and/or Modifiable Directing Groups

Zhang Wei, Zhang Jiahui, Liu Yunkui   

  1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2013-08-10 Revised:2013-09-26 Published:2013-09-30
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172197), the Natural Science Foundation of Zhejiang Province (No. Y4100201), the Foundation of Science and Technology Department of Zhejiang Province (No. 2011R09002-09).

Transition-metal catalyzed chelation-assisted C—H bond functionalization is one of hot topics in current organic chemistry. Recently, using removable and/or modifiable directing groups for C—H bond functionalizations has being received specially attention and developed rapidly. By taking advantage of removable and/or modifiable directing groups, it not only greatly expands the scope of substrates for C—H fuctionalization, but also plays important roles in rapid construction of molecule diversity. Based on the classification according to different hetero-atom (N, O, S, and Si) donors, this review presents the state of the art in design of removable and/or modifiable directing groups for transition-metal catalyzed C—H functionalizations and their application in construction of molecule diversity. Finally, the existing problems and limitations of this field are summarized, and the outlook of the area is also prospected.

Key words: directing group, C—H bond functionalization, transition-metal catalysis, molecule diversity