Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (12): 4157-4167.DOI: 10.6023/cjoc202305029 Previous Articles     Next Articles



王芳, 王磊*()   

  1. 台州学院医药化工学院 高等研究院和药学院 浙江台州 318000
  • 收稿日期:2023-05-24 修回日期:2023-07-11 发布日期:2023-08-16
  • 基金资助:
    浙江省自然科学基金(LZ22B020003); 国家自然科学基金(22071171)

Recent Advances in Functionalization of Aromatic C(sp2)—H Bonds Based on N-Nitroso Direction

Fang Wang, Lei Wang*()   

  1. School of Pharmaceutical and Chemical Engineering, Advanced Research Institute and College of Pharmaceutical Sciences, Taizhou University, Taizhou, Zhejiang 318000
  • Received:2023-05-24 Revised:2023-07-11 Published:2023-08-16
  • Contact: *E-mail:
  • Supported by:
    Natural Science Foundation of Zhejiang Province(LZ22B020003); National Natural Science Foundation of China(22071171)

In recent years, examples of activation of aromatic C(sp2)—H bonds successfully constructing C—C bonds and C—heteroatom bonds through N-nitroso synergistic chelation with transition metals have been reported. It is based on the oxidative cleavage of internal N—N bonds, and does not require the addition of external oxidants during the reaction process. After the reaction completion, it can leave on its own, which has made it develop into a new and efficient directing group, and has received widespread attention from researchers. The latest research progress on functionalization of aromatic C(sp2)—H bonds based on N-nitroso direction is summarized.

Key words: C—H bond activation, directing group, N-nitroso, aromatic functionalization