Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (4): 662-680.DOI: 10.6023/cjoc201310039 Previous Articles     Next Articles

Reviews

含氟药物研究进展和芳(杂)环氟化及N(n=1,2,3)氟甲基化新方法

张霁, 金传飞, 张英俊   

  1. 广东东阳光集团 药业研究院 东莞 523871
  • 收稿日期:2013-10-29 修回日期:2013-12-09 出版日期:2014-04-25 发布日期:2013-12-19
  • 通讯作者: 张霁 E-mail:zhangji@hecpharm.com
  • 基金资助:

    广东省引进创新科研团队计划资助项目

Recent Advances in Research and Development of Fluorinated Drugs and New Methods for Fluorination, Mono-, Di-and Tri-fluoromethylation

Zhang Ji, Jin Chuanfei, Zhang Yingjun   

  1. HEC Pharm Group, HEC Research and Development Center, Dongguan 523871
  • Received:2013-10-29 Revised:2013-12-09 Online:2014-04-25 Published:2013-12-19
  • Supported by:

    Project supported by the Introduction of Innovative R&D Team Program of Guangdong Province.

This review outlines the recent advances of fluorinated drugs and latest research overview from the perspective of a medicinal chemist wherein the synthesis and use of trifluoromethylation, difluoromethylation, monofluoromethylation and fluorinated aromatic (heterocyclic) compounds are highlighted. It is pointed out that the full use of the latest progress in fluorine chemistry provides a shortcut to new fluorinated compounds or previously difficult to prepare compounds which is worth exploring for drug discovery.

Key words: fluorine, fluorinated drugs, fluorination, trifluoromethylation, difluoromethylation, monofluoromethylation, drug design