Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (6): 1227-1230.DOI: 10.6023/cjoc201311035 Previous Articles     Next Articles



郎明, 颜瑞佐, 王玉强, 于沛   

  1. 暨南大学药学院 广州 510632
  • 收稿日期:2013-11-20 修回日期:2014-01-15 发布日期:2014-02-14
  • 通讯作者: 于沛
  • 基金资助:

    广州市国际科技合作(No. 11S52070024)资助项目.

A Selective O- and N-Acylation Protocol for Carbamyl Chloride

Lang Ming, Yan Ruizuo, Wang Yuqiang, Yu Pei   

  1. College of Pharmacy, Jinan University, Guangzhou 510632
  • Received:2013-11-20 Revised:2014-01-15 Published:2014-02-14
  • Supported by:

    Project supported by the Guangzhou International Science and Technology Cooperation Projects (No. 11S52070024).

A practical and efficient selective O- and N-acylation protocol for carbamyl chloride by using different bases was developed. The structures of the products were identified by 1H NMR, 13H NMR, ESI-MS and HRMS. The mechanism for the selective acylation is proposed.

Key words: carbamyl chloride, acylation, selectivity, synthetic method