Recent Advances on Construction of Pyrrolophenanthridone Skeleton

doi:10.6023/cjoc201404041

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (10): 1966-1977.DOI: 10.6023/cjoc201404041 Previous Articles Next Articles

Reviews

吡咯并菲啶酮构建方法学研究进展

丛蔚^a,b, 徐进宜^a,b, 姚和权^a,b

a. 中国药科大学天然药物活性组分与药效国家重点实验室南京 210009;
b. 中国药科大学药学院南京 210009

收稿日期:2014-04-22 修回日期:2014-05-29 发布日期:2014-06-16
通讯作者: 徐进宜, 姚和权 E-mail:hyao@cpu.edu.cn;jinyixu@china.com
基金资助:
国家自然科学基金（No. 21272276）和长江学者和创新团队发展计划（No. IRT1193）资助项目.

Recent Advances on Construction of Pyrrolophenanthridone Skeleton

Cong Wei^a,b, Xu Jinyi^a,b, Yao Hequan^a,b

a. State Key Laboratory of Natural Medicines SKLNM, China Pharmaceutical University, Nanjing 210009;
b. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009

Received:2014-04-22 Revised:2014-05-29 Published:2014-06-16
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21272276) and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1193).

Pyrrolophenanthridone is a common structural motif existedexisting in a number of amaryllidaceae alkaloids,many of which possess a wide range of biological activities. The intriguing structural feature and significant biological activity have attracted much attention from synthetic communities. In the past decades, several excellent synthetic methodologies have been reported, in which intramolecular or intermolecular cross-coupling reaction through transition-metal catalyzed or radical pathway represents the most straightforward method for construction of this skeleton. This review focuses on the construction of pyrrolophenanthridone skeleton and total synthesis of amaryllidaceae alkaloids.

Key words: pyrrolophenanthridone, methodology, cross-coupling reaction, transition-metal catalyzed, radical reaction

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Cong Wei, Xu Jinyi, Yao Hequan. Recent Advances on Construction of Pyrrolophenanthridone Skeleton[J]. Chin. J. Org. Chem., 2014, 34(10): 1966-1977.

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吡咯并菲啶酮构建方法学研究进展

Recent Advances on Construction of Pyrrolophenanthridone Skeleton

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