Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (1): 207-211.DOI: 10.6023/cjoc201406016 Previous Articles     Next Articles



杨振平, 王兵南, 许孝良, 王红, 李小年   

  1. 浙江工业大学化工学院 杭州 310014
  • 收稿日期:2014-06-13 修回日期:2014-09-29 发布日期:2014-10-13
  • 通讯作者: 许孝良, 王红;
  • 基金资助:

    浙江省自然科学基金(No. LY12B02017)资助项目.

Dimerization Coupling Reaction of Terminal Alkyne Promoted by CuI/DEAD

Yang Zhenping, Wang Bingnan, Xu Xiaoliang, Wang Hong, Li Xiaonian   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2014-06-13 Revised:2014-09-29 Published:2014-10-13
  • Supported by:

    Project supported by the Zhejiang Provincial Natural Science Foundation of China (No. LY12B02017).

The dimerization coupling reaction of terminal alkynes is an important method for the synthesis of conjugated carbon-carbon triple bond compounds. Catalyzed by CuI and assisted by diethyl azodicarboxylate, a variety of aromatic and aliphatic alkynes could be dimerized to give the Glaser coupling products using a catalytic amount of N-methylimidazole as a base. The effect of copper catalysts and solvents on this reaction was surveyed. It has the advantage of high yields, simple operation, and mild reaction condition.

Key words: CuI, diethyl azodicarboxylate, terminal alkyne, Glaser reaction